Detail Information
P450 Protein:
| P450 Symbol | CYP79F1 |
| Protein Name | Dihomomethionine N-hydroxylase |
| Uniprot ID | Q949U1 |
| EC Number | 1.14.14.42 |
| Gene ID | 838211 |
| Species | Arabidopsis thaliana (Mouse-ear cress) |
| Txid | 3702 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C7H15NO2S + C17H21N4O9P-2 + O2 → C6H13NOS + C17H18N4O9P-3 + CO2 + H2O + H+ |
| Reaction Type | Oxidoreduction |
| Chemical Bond | CH-NH2;Carboxyl |
| RheaID | 32719 |
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CYP79F1
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Substrate Information:
| Substrate Name | L-Dihomomethionine |
| Substrate Chemical Formula | C7H15NO2S |
| Substrate PubChem CID | 57370983 |
| Substrate Smiles | CSCCCC[C@@H](C(=O)O)N |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | (E)-5-(Methylsulfanyl)Pentanal Oxime |
| Product Chemical Formula | C6H13NOS |
| Product PubChem CID | 25010757 |
| Product Smiles | CSCCCC/C=N/O |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | CO2 |
| Product Chemical Formula | CO2 |
| Product PubChem CID | 280 |
| Product CAS Number | 124-38-9 |
| Product Smiles | O=C=O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Cytochrome p450 CYP79F1 from arabidopsis catalyzes the conversion of dihomomethionine and trihomomethionine to the corresponding aldoximes in the biosynthesis of aliphatic glucosinolates. |
| PMID: | 11133994 |
| Journal: | The Journal of biological chemistry |
| Year: | 2001/4/6 |
| Title: | CYP79F1 and CYP79F2 have distinct functions in the biosynthesis of aliphatic glucosinolates in Arabidopsis. |
| PMID: | 12609033 |
| Journal: | The Plant journal : for cell and molecular biology |
| Year: | 2003/3/1 |