Detail Information
P450 Protein:
| P450 Symbol | CYP2S1 |
| Protein Name | Cytochrome P450 2S1 |
| Uniprot ID | Q96SQ9 |
| EC Number | 1.14.14.-; 4.2.1.152; 5.3.99.5 |
| Gene ID | 29785 |
| Species | Homo sapiens (Human) |
| Txid | 9606 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein Microsome membrane; Peripheral membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H32O5 → C17H27O3- + C3H4O2 |
| Reaction Type | Oxidation |
| Chemical Bond | O-O |
| RheaID | 48644 |
CYP2S1
+
Substrate Information:
| Substrate Name | Prostaglandin H2 |
| Substrate Chemical Formula | C20H32O5 |
| Substrate PubChem CID | 445049 |
| Substrate Smiles | CCCCC[C@@H](/C=C/[C@H]1[C@H]2C[C@@H]([C@@H]1C/C=CCCCC(=O)O)OO2)O |
| Substrate Structure |
Product Information:
| Product Name | (12S)-Hydroxy-(5Z,8E,10E)-Heptadecatrienoate |
| Product Chemical Formula | C17H27O3- |
| Product PubChem CID | 102571778 |
| Product Smiles | CCCCC[C@@H](/C=C/C=C/C/C=CCCCC(=O)[O-])O |
| Product Structure |
| Product Name | malonaldehyde |
| Product Chemical Formula | C3H4O2 |
| Product PubChem CID | 10964 |
| Product Smiles | C(C=O)C=O |
| Product Structure |
References:
| Title: | Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids. |
| PMID: | 21068195 |
| Journal: | Drug metabolism and disposition: the biological fate of chemicals |
| Year: | 2011/2/1 |