Detail Information

P450 Protein:

P450 SymbolCYP170A1
Protein NameBifunctional albaflavenone monooxygenase/terpene synthase
Uniprot IDQ9K498
EC Number1.14.15.39; 4.2.3.47
Gene ID 1100664
SpeciesStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Txid 100226
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location/
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C15H24 + Fe2S2 + O2 + H+ → C15H24O + Fe2S2 + H2O
Reaction TypeOxidation
Chemical BondCH2
RheaID 25984

Epi-Isozizaene

+

[2Fe-2S]1+

+

O2

+

H+

CYP170A1

(5R)-albaflavenol

+

[2Fe-2S]2+

+

H2O

Substrate Information:

Substrate Name Epi-Isozizaene
Substrate Chemical FormulaC15H24
Substrate PubChem CID23724686
Substrate SmilesC[C@H]1CCC2=C(C([C@H]3CC[C@@]12C3)(C)C)C
Substrate Structure
Substrate Name [2Fe-2S]1+
Substrate Chemical FormulaFe2S2
Substrate SmilesS1[Fe]S[Fe+]1
Substrate Structure
Substrate Name O2
Substrate Chemical FormulaO2
Substrate PubChem CID977
Substrate CAS Number7782-44-7
Substrate SmilesO=O
Substrate Structure
Substrate Name H+
Substrate Chemical FormulaH+
Substrate PubChem CID1038
Substrate CAS Number12408-02-5
Substrate Smiles[H+]
Substrate Structure

Product Information:

Product Name (5R)-albaflavenol
Product Chemical FormulaC15H24O
Product PubChem CID25137936
Product SmilesC[C@H]1C[C@H](C2=C(C([C@H]3CC[C@@]12C3)(C)C)C)O
Product Structure
Product Name [2Fe-2S]2+
Product Chemical FormulaFe2S2
Product SmilesS1[Fe+]S[Fe+]1
Product Structure
Product Name H2O
Product Chemical FormulaH2O
Product PubChem CID962
Product CAS Number7732-18-5
Product SmilesO
Product Structure

References:

Title: Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2).
PMID: 18234666
Journal: The Journal of biological chemistry
Year: 2008/3/28

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics