Detail Information

P450 Protein:

P450 Symbol	tylH1
Protein Name	20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
Uniprot ID	Q9ZHQ1
EC Number	1.14.15.34
Species	Streptomyces fradiae (Streptomyces roseoflavus)
Txid	1906
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO

Reaction Scheme:

(4R,5S,6S,7S,9R,11E,13E,15S,16R)-7,16-diethyl-4,6-dihydroxy-5,9,13,15-tetramethyloxacyclohexadeca-11,13-diene-2,10-dione

tylH1

(4R,5S,6S,7S,9R,11E,13E,15R,16R)-7,16-diethyl-4,6-dihydroxy-15-(hydroxymethyl)-5,9,13-trimethyloxacyclohexadeca-11,13-diene-2,10-dione

Substrate Information:

Substrate Name	(4R,5S,6S,7S,9R,11E,13E,15S,16R)-7,16-diethyl-4,6-dihydroxy-5,9,13,15-tetramethyloxacyclohexadeca-11,13-diene-2,10-dione
Substrate Chemical Formula	C23H38O5
Substrate Smiles	CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](CC)C[C@@H](C)C(=O)/C=C/C(/C)=C/[C@@H]1C
Substrate Structure	Download SDF

Product Information:

Product Name	(4R,5S,6S,7S,9R,11E,13E,15R,16R)-7,16-diethyl-4,6-dihydroxy-15-(hydroxymethyl)-5,9,13-trimethyloxacyclohexadeca-11,13-diene-2,10-dione
Product Chemical Formula	C23H38O6
Product Smiles	CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](CC)C[C@@H](C)C(=O)/C=C/C(/C)=C/[C@@H]1CO
Product Structure	Download SDF

References:

Title:	Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation
PMID:	26690878
Journal:	Chembiochem : a European journal of chemical biology
Year:	2016/3/2