Detail Information
P450 Protein:
| P450 Symbol | CYP76AJ1 |
| Protein Name | Drimenol monooxygenase |
| Uniprot ID | W0FKI0 |
| EC Number | 1.14.14.72 |
| Species | Persicaria hydropiper (Marshpepper knotweed) (Polygonum hydropiper) |
| Txid | 46901 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein Microsome membrane; Peripheral membrane protein |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C15H26O + C17H21N4O9P-2 + O2 → C15H26O2 + C17H18N4O9P-3 + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH3 |
| RheaID | 55504 |
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CYP76AJ1
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Substrate Information:
| Substrate Name | (5S,9S,10S)-Drim-7-En-11-Ol |
| Substrate Chemical Formula | C15H26O |
| Substrate PubChem CID | 3080551 |
| Substrate Smiles | CC1=CC[C@@H]2[C@@]([C@H]1CO)(CCCC2(C)C)C |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | (5S,10S)-(9R)-7-Drimene-11,12-Diol |
| Product Chemical Formula | C15H26O2 |
| Product PubChem CID | 11064467 |
| Product Smiles | C[C@]12CCCC([C@@H]1CC=C([C@@H]2CO)CO)(C)C |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Identification of a drimenol synthase and drimenol oxidase from Persicaria hydropiper, involved in the biosynthesis of insect deterrent drimanes. |
| PMID: | 28258968 |
| Journal: | The Plant journal : for cell and molecular biology |
| Year: | 2017/6/1 |