Detail Information
P450 Protein:
| P450 Symbol | CYP105AS1 |
| Protein Name | Cytochrome P450 monooxygenase CYP105AS1 |
| Uniprot ID | W5VH56 |
| Species | Amycolatopsis orientalis (Nocardia orientalis) |
| Txid | 31958 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | / |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C23H34O5 → C23H35NaO7 |
| Reaction Type | Oxidation |
| Chemical Bond | C-O |
CYP105AS1
Substrate Information:
| Substrate Name | Mevastatin |
| Substrate Chemical Formula | C23H34O5 |
| Substrate PubChem CID | 64715 |
| Substrate Smiles | CC[C@H](C)C(=O)O[C@H]1CCC=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O |
| Substrate Structure |
Product Information:
| Product Name | 6-Epi-Pravastatin |
| Product Chemical Formula | C23H35NaO7 |
| Product PubChem CID | 42630641 |
| Product Smiles | CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)[O-])O)O)O.[Na+] |
| Product Structure |
References:
| Title: | Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum. |
| PMID: | 25691737 |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Year: | 2015/3/3 |