Detail Information
P450 Protein:
| P450 Symbol | CYP102A1 |
| Protein Name | P450 BM3 double mutant (Asp251Gly/Gln307His)/P450 BM3 A2 |
| Uniprot ID | |
| Species | Priestia megaterium |
| Txid | 1348623 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
| Remarks | Mutations versus WT:D251G/Q307H |
Reaction Scheme:
| Chemical Conversion | C8H8 → C8H8O |
| Reaction Type | Oxidation |
| Chemical Bond | C=C |
CYP102A1
Substrate Information:
| Substrate Name | Styrene |
| Substrate Chemical Formula | C8H8 |
| Substrate PubChem CID | 7501 |
| Substrate Smiles | C=CC1=CC=CC=C1 |
| Substrate Structure |
Product Information:
| Product Name | Styrene oxide |
| Product Chemical Formula | C8H8O |
| Product PubChem CID | 7276 |
| Product Smiles | C1C(O1)C2=CC=CC=C2 |
| Product Structure |
References:
| Title: | Biocatalytic conversion of the natural compound bergamottin into novel bioactive epoxy-derivatives using engineered cytochrome P450 BM3. |
| PMID: | 40684723 |
| Journal: | Bioorganic Chemistry |
| Year: | 2025/7/14 |