Detail Information

P450 Protein:

P450 Symbol	CYP102A1
Protein Name	P450 BM3 double mutant (Asp251Gly/Gln307His)/P450 BM3 A2
Uniprot ID
Species	Priestia megaterium
Txid	1348623
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO
Remarks	Mutations versus WT:D251G/Q307H

Reaction Scheme:

4-{[(2E)-3,7-dimethylocta-2,6-dienyl]oxy}-3,7-dihydro-2H-furo[3,2-g]chromen-7-one

CYP102A1

4-{[(2E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-enyl]oxy}-3,7-dihydro-2H-furo[3,2-g]chromen-7-one

Substrate Information:

Substrate Name	4-{[(2E)-3,7-dimethylocta-2,6-dienyl]oxy}-3,7-dihydro-2H-furo[3,2-g]chromen-7-one
Substrate Chemical Formula	C21H24O4
Substrate Smiles	C1C2=C(C=CC(O2)=O)C(=C2CCOC=12)OC/C=C(C)/CC/C=C(C)/C
Substrate Structure	Download SDF

Product Information:

Product Name	4-{[(2E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-enyl]oxy}-3,7-dihydro-2H-furo[3,2-g]chromen-7-one
Product Chemical Formula	C21H24O5
Product Smiles	C1C2=C(C=CC(O2)=O)C(=C2CCOC=12)OC/C=C(C)/CCC1OC1(C)C
Product Structure	Download SDF

References:

Title:	Biocatalytic conversion of the natural compound bergamottin into novel bioactive epoxy-derivatives using engineered cytochrome P450 BM3.
PMID:	40684723
Journal:	Bioorganic Chemistry
Year:	2025/7/14