Detail Information

P450 Protein:

P450 SymbolCYP720B1
Protein NameCYP720B1
Uniprot IDA0A076U5L2
SpeciesPinus contorta
Txid 3339
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C20H32 → C20H30O2
Reaction TypeOxidation
Chemical BondCH

Sandaracopimaradiene

CYP720B1

(1S,4aR,4bS,7R,10aR)-7-ethenyl-1,4a,7-trimethyl-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid

Substrate Information:

Substrate Name Sandaracopimaradiene
Substrate Chemical FormulaC20H32
Substrate PubChem CID443469
Substrate SmilesC[C@@]1(CC[C@H]2C(=C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C)C=C
Substrate Structure

Product Information:

Product Name (1S,4aR,4bS,7R,10aR)-7-ethenyl-1,4a,7-trimethyl-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid
Product Chemical FormulaC20H30O2
Product PubChem CID12309236
Product SmilesC[C@@]1(CC[C@H]2C(=C1)CC[C@@H]3[C@@]2(CCC[C@]3(C)C(=O)O)C)C=C
Product Structure

References:

Title: Divergent multifunctional P450s-empowered biosynthesis of bioactive?tripterifordin and cryptic atiserenoids in Aconitum implies convergent evolution.
PMID: 40595667
Journal: Nature communications
Year: 2025/7/1

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics