Detail Information
P450 Protein:
| P450 Symbol | CYP76AH8 |
| Protein Name | Cytochrome P450 CYP76AH8 |
| Uniprot ID | A0A1B0VRP1 |
| Species | Plectranthus barbatus |
| Txid | 41228 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H34O → C20H34O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
CYP76AH8
Substrate Information:
| Substrate Name | 13(R)-Manoyl Oxide |
| Substrate Chemical Formula | C20H34O |
| Substrate PubChem CID | 6432025 |
| Substrate Smiles | C[C@@]1(CC[C@@H]2[C@]3(CCCC([C@@H]3CC[C@]2(O1)C)(C)C)C)C=C |
| Substrate Structure |
Product Information:
| Product Name | 1,11-dihydroxy-13R-manoyl oxide |
| Product Chemical Formula | C20H34O3 |
| Product Smiles | C=C[C@@]1(O[C@@](C)2CCC3C(C)(C)CCC(O)[C@]3(C)C2C(O)C1)C |
| Product Structure |
References:
| Title: | Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii. |
| PMID: | 28290983 |
| Journal: | eLife |
| Year: | 2017/3/14 |