Detail Information

P450 Protein:

P450 Symbol	CYP72A1
Protein Name
Uniprot ID
Species	Aconitum coreanum
Txid	85363
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO

Reaction Scheme:

(4R,9R,10R)-5,5,9-trimethyl-13-methylidenetetracyclo[10.2.2.01,10.04,9]hexadecane

CYP72A1

(4S,6R,9R,10R)-9-(hydroxymethyl)-5,5-dimethyl-16-methylidenetetracyclo[10.2.2.01,10.04,9]hexadecan-6-ol

Substrate Information:

Substrate Name	(4R,9R,10R)-5,5,9-trimethyl-13-methylidenetetracyclo[10.2.2.01,10.04,9]hexadecane
Substrate Chemical Formula	C20H32
Substrate PubChem CID	129626773
Substrate Smiles	C[C@@]12CCCC([C@H]1CCC34[C@H]2CC(CC3)C(=C)C4)(C)C
Substrate Structure	Download SDF

Product Information:

Product Name	(4S,6R,9R,10R)-9-(hydroxymethyl)-5,5-dimethyl-16-methylidenetetracyclo[10.2.2.01,10.04,9]hexadecan-6-ol
Product Chemical Formula	C20H32O2
Product Smiles	[C@]([H])12[C@](CC[C@@H](O)[C@@]1(C)C)(CO)[C@@]([H])1CC3CCC1(CC3=C)CC2
Product Structure	Download SDF

References:

Title:	Divergent multifunctional P450s-empowered biosynthesis of bioactive?tripterifordin and cryptic atiserenoids in Aconitum implies convergent evolution.
PMID:	40595667
Journal:	Nature communications
Year:	2025/7/1