Detail Information
P450 Protein:
| P450 Symbol | CYP71A1 |
| Protein Name | |
| Uniprot ID | |
| Species | Aconitum coreanum |
| Txid | 85363 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H32 → C21H32O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP71A1
Substrate Information:
| Substrate Name | (4R,9R,10R)-5,5,9-trimethyl-13-methylidenetetracyclo[10.2.2.01,10.04,9]hexadecane |
| Substrate Chemical Formula | C20H32 |
| Substrate PubChem CID | 129626773 |
| Substrate Smiles | C[C@@]12CCCC([C@H]1CCC34[C@H]2CC(CC3)C(=C)C4)(C)C |
| Substrate Structure |
Product Information:
| Product Name | (1S,2R,10R,11R,14R,18R)-14-methoxy-11-methyl-19-methylidene-13-oxapentacyclo[9.3.3.24,7.02,7.01,10]nonadecan-18-ol |
| Product Chemical Formula | C21H32O3 |
| Product Smiles | [C@]([H])12[C@@]3(CCC[C@@]1(C)CO[C@H]3OC)[C@@]([H])1CC3CCC1([C@H](O)C3=C)CC2 |
| Product Structure |
References:
| Title: | Divergent multifunctional P450s-empowered biosynthesis of bioactive?tripterifordin and cryptic atiserenoids in Aconitum implies convergent evolution. |
| PMID: | 40595667 |
| Journal: | Nature communications |
| Year: | 2025/7/1 |