Detail Information
P450 Protein:
| P450 Symbol | CYP88A164 |
| Protein Name | (21S)-21-acetyl-1-hydroxy-apo-melianone synthase CYP88A164 |
| Uniprot ID | P0DXH4 |
| EC Number | 1.14.14.- |
| Species | Melia azedarach |
| Txid | 155640 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C31H50O2 → C31H48O2 |
| Reaction Type | Oxidation |
| Chemical Bond | C-OH |
CYP88A164
Substrate Information:
| Substrate Name | 11Alpha-hydroxy-beta-amyrin |
| Substrate Chemical Formula | C31H50O2 |
| Substrate Smiles | [C@](C)12CC[C@H](O)[C@](C)(C=C)[C@]1([H])CC[C@@](C)1[C@]2([H])[C@H](O)C=C2[C@@]([H])3C[C@@](C)(CC[C@@]3(CC[C@@]12C)C)C |
| Substrate Structure |
Product Information:
| Product Name | 11-Oxo-beta-amyrin |
| Product Chemical Formula | C31H48O2 |
| Product Smiles | [C@](C)12CC[C@H](O)[C@](C)(C=C)[C@]1([H])CC[C@@](C)1[C@]2([H])C(=O)C=C2[C@@]([H])3C[C@@](C)(CC[C@@]3(CC[C@@]12C)C)C |
| Product Structure |
References:
| Title: | Three cytochrome P450 88A subfamily enzymes, CYP88A108, CYP88A164, and CYP88A222, act as β-amyrin 11-oxidases involved in triterpenoid biosynthesis in Melia azedarach L. |
| PMID: | 40541870 |
| Journal: | International Journal of Biological Macromolecule |
| Year: | 2025/6/18 |