Detail Information

P450 Protein:

P450 SymbolTlnA
Protein Name
Uniprot ID
SpeciesStreptomyces sp. S6043a
Txid 1931
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C11H16O2S → C11H14O2S
Reaction TypeCyclization
Chemical BondC=O

(2S,4E,6E)-2,4,6-trimethyl-3-oxoocta-4,6-dienethioic S-acid

TlnA

(5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1,3-dienyl]-2,5-dihydrothiophen-2-one

Substrate Information:

Substrate Name (2S,4E,6E)-2,4,6-trimethyl-3-oxoocta-4,6-dienethioic S-acid
Substrate Chemical FormulaC11H16O2S
Substrate SmilesSC([C@@H](C)C(/C(/C)=C/C(/C)=C/C)=O)=O
Substrate Structure

Product Information:

Product Name (5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1,3-dienyl]-2,5-dihydrothiophen-2-one
Product Chemical FormulaC11H14O2S
Product SmilesO=C1C(C)=C([C@](/C=C(/C=C)C)(C)S1)O
Product Structure

References:

Title: Deciphering the Thiolactonization Mechanism in Thiolactomycin Biosynthesis.
PMID: 40537968
Journal: Journal of the American Chemical Society
Year: 2025/6/19

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics