Detail Information
P450 Protein:
| P450 Symbol | CYP71CA1 |
| Protein Name | CYP71CA1 variant Y22G |
| Uniprot ID | |
| Species | Tanacetum parthenium (Feverfew) (Matricaria parthenium) |
| Txid | 127999 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
| Remarks | Mutations versus WT:Y22G |
Reaction Scheme:
| Chemical Conversion | C15H20O2 → C15H20O3 |
| Reaction Type | Oxidation |
| Chemical Bond | C=C |
CYP71CA1
Substrate Information:
| Substrate Name | (1S,4E,8E,10S)-4,8-dimethyl-13-methylidene-11-oxabicyclo[8.3.0]trideca-4,8-dien-12-one |
| Substrate Chemical Formula | C15H20O2 |
| Substrate Smiles | C1/C(/C)=C/[C@H]2[C@H](C(=C)C(O2)=O)CC/C(=C/C1)/C |
| Substrate Structure |
Product Information:
| Product Name | (1R,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one |
| Product Chemical Formula | C15H20O3 |
| Product Smiles | C1[C@]2(O[C@@H]2[C@H]2[C@H](C(=C)C(O2)=O)CC/C(=C/C1)/C)C |
| Product Structure |
References:
| Title: | Engineering the cytochrome P450 to enhance parthenolide production in Saccharomyces cerevisiae. |
| PMID: | 40488110 |
| Journal: | Synth Syst Biotechnol |
| Year: | 2025/5/2 |