Detail Information
P450 Protein:
| P450 Symbol | CYP80B |
| Protein Name | |
| Uniprot ID | |
| Species | Stephania tetrandra |
| Txid | 425106 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C17H19NO3 → C17H19NO4 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP80B
Substrate Information:
| Substrate Name | (S)-Coclaurine |
| Substrate Chemical Formula | C17H19NO3 |
| Substrate PubChem CID | 160487 |
| Substrate Smiles | COC1=C(C=C2[C@@H](NCCC2=C1)CC3=CC=C(C=C3)O)O |
| Substrate Structure |
Product Information:
| Product Name | (S)-3′-Hydroxycoclaurine |
| Product Chemical Formula | C17H19NO4 |
| Product PubChem CID | 441067 |
| Product Smiles | COC1=C(C=C2[C@@H](NCCC2=C1)CC3=CC(=C(C=C3)O)O)O |
| Product Structure |
References:
| Title: | A CYP80B enzyme from Stephania tetrandra enables the 3'-hydroxylation of N-methylcoclaurine and coclaurine in the biosynthesis of benzylisoquinoline alkaloids. |
| PMID: | 40383618 |
| Journal: | Chinese Journal of Natural Medicines |
| Year: | 2025/5/20 |