Detail Information

P450 Protein:

P450 SymbolCYP80B
Protein Name
Uniprot ID
SpeciesStephania tetrandra
Txid 425106
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C18H21NO3 → C18H21NO4
Reaction TypeOxidation
Chemical BondCH

(S)-N-Methylcoclaurine

CYP80B

(S)-3′-Hydroxy-N-Methylcoclaurine

Substrate Information:

Substrate Name (S)-N-Methylcoclaurine
Substrate Chemical FormulaC18H21NO3
Substrate PubChem CID440584
Substrate SmilesCN1CCC2=CC(=C(C=C2[C@@H]1CC3=CC=C(C=C3)O)O)OC
Substrate Structure

Product Information:

Product Name (S)-3′-Hydroxy-N-Methylcoclaurine
Product Chemical FormulaC18H21NO4
Product PubChem CID440591
Product SmilesCN1CCC2=CC(=C(C=C2[C@@H]1CC3=CC(=C(C=C3)O)O)O)OC
Product Structure

References:

Title: A CYP80B enzyme from Stephania tetrandra enables the 3'-hydroxylation of N-methylcoclaurine and coclaurine in the biosynthesis of benzylisoquinoline alkaloids.
PMID: 40383618
Journal: Chinese Journal of Natural Medicines
Year: 2025/5/20

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics