Detail Information
P450 Protein:
| P450 Symbol | CYP80B |
| Protein Name | |
| Uniprot ID | |
| Species | Stephania tetrandra |
| Txid | 425106 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C18H23NO3 → C18H23NO4 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP80B
Substrate Information:
| Substrate Name | N-Methylcoclaurine |
| Substrate Chemical Formula | C18H23NO3 |
| Substrate Smiles | C1=C(O)C=CC(CC2N(C)CCC3C=C(OC)C(O)=CC23)=C1 |
| Substrate Structure |
Product Information:
| Product Name | 3′-OH-N-Methylcoclaurine |
| Product Chemical Formula | C18H23NO4 |
| Product Smiles | C(O)1=C(O)C=CC(CC2N(C)CCC3C=C(OC)C(O)=CC23)=C1 |
| Product Structure |
References:
| Title: | A CYP80B enzyme from Stephania tetrandra enables the 3'-hydroxylation of N-methylcoclaurine and coclaurine in the biosynthesis of benzylisoquinoline alkaloids. |
| PMID: | 40383618 |
| Journal: | Chinese Journal of Natural Medicines |
| Year: | 2025/5/20 |