Detail Information

P450 Protein:

P450 SymbolCYP71BE50
Protein Name
Uniprot ID
SpeciesAndrographis Paniculata
Txid 175694
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO
RemarksGenBase: C_AA104980.1

Reaction Scheme:

Chemical Conversion C20H34O3 → C20H32O3
Reaction TypeOxidation
Chemical BondC-OH

ent-8(17),13-diene-15,16,19-triol

CYP71BE50

ent-labda-8(17),13-dien-15,19-diol-16-enal

Substrate Information:

Substrate Name ent-8(17),13-diene-15,16,19-triol
Substrate Chemical FormulaC20H34O3
Substrate Smiles[H][C@@]1([C@](C)2[C@]([H])(CCC1=C)[C@](CO)(CCC2)C)CC/C(/CO)=C/CO
Substrate Structure

Product Information:

Product Name ent-labda-8(17),13-dien-15,19-diol-16-enal
Product Chemical FormulaC20H32O3
Product Smiles[H][C@@]1([C@](C)2[C@]([H])(CCC1=C)[C@](CO)(CCC2)C)CC/C(/C=O)=C/CO
Product Structure

References:

Title: Completing the Biosynthesis of the Clinically Important Diterpenoid Andrographolide in Andrographis Paniculata.
PMID: 40364767
Journal: Angew Chem Int Ed Engl
Year: 2025/5/14

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
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