Detail Information
P450 Protein:
| P450 Symbol | dtpC |
| Protein Name | Cytochrome P450 |
| Uniprot ID | A0A7U2QZH8 |
| Species | Aspergillus flavus |
| Txid | 332952 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C17H21N3O2 → C34H40N6O4 |
| Reaction Type | Dimerization |
| Chemical Bond |
dtpC
Substrate Information:
| Substrate Name | Cyclo(L-leucyl-L-tryptophyl) |
| Substrate Chemical Formula | C17H21N3O2 |
| Substrate PubChem CID | 3082081 |
| Substrate Smiles | CC(C)C[C@H]1C(=O)N[C@H](C(=O)N1)CC2=CNC3=CC=CC=C32 |
| Substrate Structure |
Product Information:
| Product Name | (3S,5aS,10bS,11aS)-3-(2-methylpropyl)-10b-[(3S,5aS,10bS,11aS)-3-(2-methylpropyl)-1,4-dioxo-2,3,4,5a,6,10b,11,11a-octahydro-1H-pyrazino[2′,1′:5,1]pyrrolo[2,3-b]indol-10b-yl]-2,3,4,5a,6,10b,11,11a-octahydro-1H-pyrazino[2′,1′:5,1]pyrrolo[2,3-b]indole-1,4-dione |
| Product Chemical Formula | C34H40N6O4 |
| Product Smiles | N1[C@@H](CC(C)C)C(=O)[N@]2[C@H]3[C@]([C@]45[C@H]([N@]6[C@@H](C4)C(=O)N[C@@H](CC(C)C)C6=O)NC4C5=CC=CC=4)(C4C(=CC=CC=4)N3)C[C@H]2C1=O |
| Product Structure |
References:
| Title: | Understanding the Scope of Cytochrome P450-Catalyzed Radical Dimerization of Diketopiperazines. |
| PMID: | 39747836 |
| Journal: | Biochemistry |
| Year: | 2025/1/2 |