Detail Information
P450 Protein:
| P450 Symbol | CYP102A1 |
| Protein Name | P450 BM3-139-3 variant |
| Uniprot ID | |
| Species | Priestia megaterium |
| Txid | 1348623 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
| Remarks | Mutations versus WT: V78A;H138Y;T175I;V178I;A184V;H236Q;E252G;R255S;A295T;L353V |
Reaction Scheme:
| Chemical Conversion | C15H24 → C15H24O |
| Reaction Type | Oxidation |
| Chemical Bond | C=C |
CYP102A1
Substrate Information:
| Substrate Name | (+)-bicyclogermacrene |
| Substrate Chemical Formula | C15H24 |
| Substrate Smiles | C/C1/CC/C=C(/CC[C@H]2C(C)(C)[C@H]2/C=1)C |
| Substrate Structure |
Product Information:
| Product Name | (+)-3,6-epoxymaaliane |
| Product Chemical Formula | C15H24O |
| Product Smiles | [H][C@@]12[C@@H]3C([C@@H]3CC[C@]1([C@]1(CC[C@]2(C)O1)[H])C)(C)C |
| Product Structure |
References:
| Title: | (+)-3,6-Epoxymaaliane: A Novel Derivative of (+)-Bicyclogermacrene Oxidation Catalyzed by CYP450 BM3-139-3?and Its Variants. |
| PMID: | 39462891 |
| Journal: | Chembiochem |
| Year: | 2024/10/27 |