Detail Information

P450 Protein:

P450 Symbol	PerX
Protein Name
Uniprot ID
Species	Actinokineospora sp UTMC 2448
Txid	2268449
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO
Remarks	GenebankID:CP031087.1

Reaction Scheme:

Chemical Conversion	C51H43N13O12S6 → C51H43N13O13S6
Reaction Type	Oxidation
Chemical Bond	CH

2-[({2-[(1S,11S,28S,42S)-8-[(1Z)-ethylidene]-20,42-dihydroxy-11-[(1R)-1-hydroxyethyl]-51-methyl-3,10,13,31,41,48-hexaoxo-2,9,12,22,33,49,52,53,54,55-decaza-40-oxa-6,16,26,30,45-pentathianonacyclo[26.15.6.232,38.144,47.124,27.14,7.114,17.034,50.018,23]pentapentaconta-4(5),7(55),14(15),17(54),18(23),19,21,24(25),27(53),32(51),34(35),36,38(50),44(52),46-pentadecaen-21-yl]-1,3-thiazol-4-yl}carbonyl)amino]prop-2-enamide

PerX

2-[({2-[(1S,11S,28S,42S)-8-[(1Z)-ethylidene]-20,42,46-trihydroxy-11-[(1R)-1-hydroxyethyl]-51-methyl-3,10,13,31,41,48-hexaoxo-2,9,12,22,33,49,52,53,54,55-decaza-40-oxa-6,16,26,30,45-pentathianonacyclo[26.15.6.232,38.144,47.124,27.14,7.114,17.034,50.018,23]pentapentaconta-4(5),7(55),14(15),17(54),18(23),19,21,24(25),27(53),32(51),34(35),36,38(50),44(52),46-pentadecaen-21-yl]-1,3-thiazol-4-yl}carbonyl)amino]prop-2-enamide

Substrate Information:

Substrate Name	2-[({2-[(1S,11S,28S,42S)-8-[(1Z)-ethylidene]-20,42-dihydroxy-11-[(1R)-1-hydroxyethyl]-51-methyl-3,10,13,31,41,48-hexaoxo-2,9,12,22,33,49,52,53,54,55-decaza-40-oxa-6,16,26,30,45-pentathianonacyclo[26.15.6.232,38.144,47.124,27.14,7.114,17.034,50.018,23]pentapentaconta-4(5),7(55),14(15),17(54),18(23),19,21,24(25),27(53),32(51),34(35),36,38(50),44(52),46-pentadecaen-21-yl]-1,3-thiazol-4-yl}carbonyl)amino]prop-2-enamide
Substrate Chemical Formula	C51H43N13O12S6
Substrate Smiles	N1/C(/C2SC=C(C(N[C@H]3C[C@@H](C(OCC4C5C(C)=C(C(SC[C@@H](C6SC=C(C7C(C8SC=C(C(N[C@H](C1=O)[C@@H](C)O)=O)N=8)=CC(=C(C1SC=C(C(=O)NC(=C)C(=O)N)N=1)N=7)O)N=6)NC(C1=CSC3=N1)=O)=O)NC=5C=CC=4)=O)O)=O)N=2)=CC
Substrate Structure	Download SDF

Product Information:

Product Name	2-[({2-[(1S,11S,28S,42S)-8-[(1Z)-ethylidene]-20,42,46-trihydroxy-11-[(1R)-1-hydroxyethyl]-51-methyl-3,10,13,31,41,48-hexaoxo-2,9,12,22,33,49,52,53,54,55-decaza-40-oxa-6,16,26,30,45-pentathianonacyclo[26.15.6.232,38.144,47.124,27.14,7.114,17.034,50.018,23]pentapentaconta-4(5),7(55),14(15),17(54),18(23),19,21,24(25),27(53),32(51),34(35),36,38(50),44(52),46-pentadecaen-21-yl]-1,3-thiazol-4-yl}carbonyl)amino]prop-2-enamide
Product Chemical Formula	C51H43N13O13S6
Product Smiles	N1/C(/C2SC=C(C(N[C@H]3C[C@@H](C(OCC4C5C(C)=C(C(SC[C@@H](C6SC=C(C7C(C8SC=C(C(N[C@H](C1=O)[C@@H](C)O)=O)N=8)=CC(=C(C1SC=C(C(=O)NC(=C)C(=O)N)N=1)N=7)O)N=6)NC(C1=C(O)SC3=N1)=O)=O)NC=5C=CC=4)=O)O)=O)N=2)=CC
Product Structure	Download SDF

References:

Title:	Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis.
PMID:	39189814
Journal:	ACS Infectious Diseases
Year:	2024/8/27