Detail Information
P450 Protein:
| P450 Symbol | CYP102A1 |
| Protein Name | CYP102A1 variant |
| Uniprot ID | |
| Species | Priestia megaterium |
| Txid | 1348623 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
| Remarks | Mutations versus WT:F11L;R47L;F81I;F87V;Q110P;E143G;L188Q;R190Q;E267V;A474V;E558D;T664A;P675L;A678E;E687A;A741G;K813E;R825S;R836H;E870N;I881V;E887G;P894S;S954N;M967V;Q981R;A1008D;H1021Y;Q1022E |
Reaction Scheme:
| Chemical Conversion | C10H16O → C10H16O2 |
| Reaction Type | Oxidation |
| Chemical Bond | C=C |
CYP102A1
Substrate Information:
| Substrate Name | Perillyl Alcohol |
| Substrate Chemical Formula | C10H16O |
| Substrate PubChem CID | 10819 |
| Substrate Smiles | CC(=C)C1CCC(=CC1)CO |
| Substrate Structure |
Product Information:
| Product Name | [4-(2-Methyloxiran-2-yl)cyclohexen-1-yl]methanol |
| Product Chemical Formula | C10H16O2 |
| Product PubChem CID | 129249959 |
| Product Smiles | CC1(CO1)C2CCC(=CC2)CO |
| Product Structure |
References:
| Title: | Epoxidation of perillyl alcohol by engineered bacterial cytochrome P450 BM3. |
| PMID: | 39079222 |
| Journal: | Enzyme and Microbial Technology |
| Year: | 2024/7/29 |