Detail Information
P450 Protein:
| P450 Symbol | CYP1A1 |
| Protein Name | Cytochrome P450 1A |
| Uniprot ID | Q0VHD5 |
| EC Number | 1.14.14.1 |
| Species | Homo sapiens |
| Txid | 9606 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H16N2O4 → C20H16N2O5 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP1A1
Substrate Information:
| Substrate Name | (+/-)Campathecin |
| Substrate Chemical Formula | C20H16N2O4 |
| Substrate PubChem CID | 2538 |
| Substrate Smiles | CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O |
| Substrate Structure |
Product Information:
| Product Name | 4-Ethyl-4,10-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Product Chemical Formula | C20H16N2O5 |
| Product PubChem CID | 135406264 |
| Product CAS Number | 130194-92-2 |
| Product Smiles | CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5O)N=C4C3=C2)O |
| Product Structure |
References:
| Title: | Development of a RNA-protein complex based smart drug delivery system for 9-hydroxycamptothecin. |
| PMID: | 39009257 |
| Journal: | International Journal of Biological Macromolecules |
| Year: | 2024/7/14 |