Detail Information

P450 Protein:

P450 Symbol	CYP725A
Protein Name
Uniprot ID
Species	Taxus x media
Txid	85957
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO

Reaction Scheme:

Chemical Conversion	C32H44O12 → C32H44O13
Reaction Type	Cyclization
Chemical Bond

taxadiene hexaacetate

CYP725A

[(1′R,2R,2′R,3′R,5′S,7′S,8′S,9′R,10′R,13′S)-2′,5′,7′,9′,10′-pentaacetyloxy-8′,12′,15′,15′-tetramethylspiro[oxirane-2,4′-tricyclo[9.3.1.03,8]pentadec-11-ene]-13′-yl] acetate

Substrate Information:

Substrate Name	taxadiene hexaacetate
Substrate Chemical Formula	C32H44O12
Substrate PubChem CID	14446189
Substrate Smiles	CC1=C2[C@H]([C@@H]([C@@]3([C@H](C[C@@H](C(=C)[C@H]3[C@@H]([C@@H](C2(C)C)C[C@@H]1OC(=O)C)OC(=O)C)OC(=O)C)OC(=O)C)C)OC(=O)C)OC(=O)C
Substrate Structure	Download SDF

Product Information:

Product Name	[(1′R,2R,2′R,3′R,5′S,7′S,8′S,9′R,10′R,13′S)-2′,5′,7′,9′,10′-pentaacetyloxy-8′,12′,15′,15′-tetramethylspiro[oxirane-2,4′-tricyclo[9.3.1.03,8]pentadec-11-ene]-13′-yl] acetate
Product Chemical Formula	C32H44O13
Product PubChem CID	21679295
Product Smiles	CC1=C2[C@H]([C@@H]([C@@]3([C@H](C[C@@H]([C@@]4([C@H]3[C@@H]([C@@H](C2(C)C)C[C@@H]1OC(=O)C)OC(=O)C)CO4)OC(=O)C)OC(=O)C)C)OC(=O)C)OC(=O)C
Product Structure	Download SDF

References:

Title:	A Cytochrome P450 Enzyme Catalyses Oxetane Ring Formation in Paclitaxel Biosynthesis.
PMID:	38712793
Journal:	Angew Chem Int Ed Engl
Year:	2024/5/7