Detail Information

P450 Protein:

P450 SymbolCYP71BE52
Protein NameSalviol synthase
Uniprot IDA0A0S1TQ04
EC Number1.14.14.62
SpeciesSalvia pomifera (Apple sage)
Txid 396869
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C20H30O2 → C20H30O3
Reaction TypeOxidation
Chemical BondCH

Isopimaric Acid

CYP71BE52

(1R,3R,4aR,4bS,7S,10aR)-3-hydroxy-1,4a,7-trimethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydrophenanthrene-1-carboxylic acid

Substrate Information:

Substrate Name Isopimaric Acid
Substrate Chemical FormulaC20H30O2
Substrate PubChem CID442048
Substrate SmilesC[C@@]1(CC[C@H]2C(=CC[C@@H]3[C@@]2(CCC[C@@]3(C)C(=O)O)C)C1)C=C
Substrate Structure

Product Information:

Product Name (1R,3R,4aR,4bS,7S,10aR)-3-hydroxy-1,4a,7-trimethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydrophenanthrene-1-carboxylic acid
Product Chemical FormulaC20H30O3
Product Smiles[H][C@@]12CC=C3C[C@@](CC[C@@H]3[C@]1(C[C@@H](O)C[C@]2(C(O)=O)C)C)(C)C=C
Product Structure

References:

Title: Combinatorial biosynthesis in yeast leads to over 200 diterpenoids.
PMID: 38387676
Journal: Metabolic Engineering
Year: 2024/2/20

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics