Detail Information

P450 Protein:

P450 SymbolCYP76AH22
Protein NameFerruginol synthase 1
Uniprot IDA0A0C5Q4Y6
EC Number1.14.14.-; 1.14.14.175; 1.14.14.60
SpeciesRosmarinus officinalis (Rosemary) (Salvia rosmarinus)
Txid 39367
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C20H34O → C20H32O2
Reaction TypeOxidation
Chemical BondCH

Nezukol

CYP76AH22

(2R,4bS,8aS,10aR)-10a-hydroxy-2,4b,8,8-tetramethyl-2-vinyltetradecahydrophenanthren-4-one

Substrate Information:

Substrate Name Nezukol
Substrate Chemical FormulaC20H34O
Substrate PubChem CID13969544
Substrate SmilesC[C@@]1(CC[C@@H]2[C@]3(CCCC([C@@H]3CC[C@]2(C1)O)(C)C)C)C=C
Substrate Structure

Product Information:

Product Name (2R,4bS,8aS,10aR)-10a-hydroxy-2,4b,8,8-tetramethyl-2-vinyltetradecahydrophenanthren-4-one
Product Chemical FormulaC20H32O2
Product Smiles[H][C@@]12CC[C@](O)3C[C@@](CC(=O)C3[C@]1(CCC[C@]2(C)C)C)(C)C=C
Product Structure

References:

Title: Combinatorial biosynthesis in yeast leads to over 200 diterpenoids.
PMID: 38387676
Journal: Metabolic Engineering
Year: 2024/2/20

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics