Detail Information
P450 Protein:
| P450 Symbol | CYP76M8 |
| Protein Name | Oryzalexin D synthase |
| Uniprot ID | Q6YTF1 |
| EC Number | 1.14.14.112; 1.14.14.123 |
| Gene ID | 4329722 |
| Species | Oryza sativa subsp. japonica (Rice) |
| Txid | 39947 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H32O3 → C20H32O4 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
CYP76M8
Substrate Information:
| Substrate Name | (1R,4aS,4bR,7S,8aR,10aR)-8a-hydroxy-1,4a,7-trimethyl-7-vinyltetradecahydrophenanthrene-1-carboxylic acid |
| Substrate Chemical Formula | C20H32O3 |
| Substrate Smiles | [H][C@@]12CC[C@](O)3C[C@@](CC[C@@H]3[C@]1(CCC[C@]2(C(=O)O)C)C)(C)C=C |
| Substrate Structure |
Product Information:
| Product Name | (1R,4aS,4bR,7S,8aS,10aR,10R)-8a,10-dihydroxy-1,4a,7-trimethyl-7-vinyltetradecahydrophenanthrene-1-carboxylic acid |
| Product Chemical Formula | C20H32O4 |
| Product Smiles | [H][C@@]12[C@H](O)C[C@](O)3C[C@@](CC[C@@H]3[C@]1(CCC[C@]2(C(=O)O)C)C)(C)C=C |
| Product Structure |
References:
| Title: | Combinatorial biosynthesis in yeast leads to over 200 diterpenoids. |
| PMID: | 38387676 |
| Journal: | Metabolic Engineering |
| Year: | 2024/2/20 |