Detail Information

P450 Protein:

P450 Symbol	PhmC
Protein Name
Uniprot ID
Species	Phoma sp. ATCC 74077
Txid	3079041
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO
Remarks	GenBank: WNN28533.1

Reaction Scheme:

(3S,5R,8E,12R,13R)-5,9,12,13-tetramethyl-16-methylidene-4-oxatricyclo[10.3.1.03,5]hexadeca-1(15),8-dien-2-one

PhmC

(3S,5R,8S,10S,13R,14R)-5,10,13,14-tetramethyl-17-methylidene-4,9-dioxatetracyclo[11.3.1.03,5.08,10]heptadec-1(16)-en-2-one

Substrate Information:

Substrate Name	(3S,5R,8E,12R,13R)-5,9,12,13-tetramethyl-16-methylidene-4-oxatricyclo[10.3.1.03,5]hexadeca-1(15),8-dien-2-one
Substrate Chemical Formula	C20H28O2
Substrate Smiles	O1[C@@H]2C(=O)C3C(=C)[C@@](C)([C@@H](CC=3)C)CC/C(/C)=C/CC[C@@]12C
Substrate Structure	Download SDF

Product Information:

Product Name	(3S,5R,8S,10S,13R,14R)-5,10,13,14-tetramethyl-17-methylidene-4,9-dioxatetracyclo[11.3.1.03,5.08,10]heptadec-1(16)-en-2-one
Product Chemical Formula	C20H28O3
Product Smiles	O1[C@@H]2C(=O)C3C(=C)[C@@](C)([C@@H](CC=3)C)CC[C@@]3(O[C@H]3CC[C@@]12C)C
Product Structure	Download SDF

References:

Title:	Biosynthesis of Phomactin Platelet Activating Factor Antagonist Requires a Two-Enzyme Cascade.
PMID:	37804495
Journal:	Angew Chem Int Ed Engl
Year:	2023/10/7