Detail Information
P450 Protein:
| P450 Symbol | cloA |
| Protein Name | Cytochrome P450 monooxygenase cloA |
| Uniprot ID | Q2PBY6 |
| Species | Claviceps purpurea |
| Txid | 5111 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C16H18N2 → C16H18N2O |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
cloA
Substrate Information:
| Substrate Name | Agroclavin |
| Substrate Chemical Formula | C16H18N2 |
| Substrate PubChem CID | 287403 |
| Substrate Smiles | CC1=CC2C(CC3=CNC4=CC=CC2=C34)N(C1)C |
| Substrate Structure |
Product Information:
| Product Name | Elymoclavin |
| Product Chemical Formula | C16H18N2O |
| Product PubChem CID | 11051 |
| Product CAS Number | 548-43-6 |
| Product Smiles | CN1CC(=CC2C1CC3=CNC4=CC=CC2=C34)CO |
| Product Structure |
References:
| Title: | Increasing lysergic acid levels for ergot alkaloid biosynthesis: Directing catalysis via the F-G loop of Clavine oxidases. |
| PMID: | 37007471 |
| Journal: | Front Microbiol |
| Year: | 2023/3/16 |