Detail Information

P450 Protein:

P450 SymbolcloA
Protein NameCytochrome P450 monooxygenase cloA
Uniprot IDQ2PBY6
SpeciesClaviceps purpurea
Txid 5111
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C16H18N2O → C16H16N2O2
Reaction TypeOxidation
Chemical BondCH

Elymoclavin

cloA

6-Methyl-8,9-didehydro-ergoline-8-carboxylic acid

Substrate Information:

Substrate Name Elymoclavin
Substrate Chemical FormulaC16H18N2O
Substrate PubChem CID11051
Substrate SmilesCN1CC(=CC2C1CC3=CNC4=CC=CC2=C34)CO
Substrate Structure

Product Information:

Product Name 6-Methyl-8,9-didehydro-ergoline-8-carboxylic acid
Product Chemical FormulaC16H16N2O2
Product PubChem CID12313992
Product SmilesCN1CC(=CC2C1CC3=CNC4=CC=CC2=C34)C(=O)O
Product Structure

References:

Title: Increasing lysergic acid levels for ergot alkaloid biosynthesis: Directing catalysis via the F-G loop of Clavine oxidases.
PMID: 37007471
Journal: Front Microbiol
Year: 2023/3/16

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics