Detail Information

P450 Protein:

P450 SymbolCYP80Q1
Protein Name(S)-N-methylcoclaurine 3'-hydroxylase isozyme 2
Uniprot ID
SpeciesNelumbo nucifera
Txid 4432
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO
RemarksGenBank: MG517489.1

Reaction Scheme:

Chemical Conversion C16H17NO3 → C16H15NO3
Reaction TypeCyclization
Chemical BondCH

Higenamine

CYP80Q1

10,11-dihydroxyspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8(9),10-triene-2,3'-cyclohexa-1,4-diene]-6'-one

Substrate Information:

Substrate Name Higenamine
Substrate Chemical FormulaC16H17NO3
Substrate PubChem CID114840
Substrate SmilesC1C2=CC(O)=C(O)C=C2C(CC2C=CC(O)=CC=2)NC1
Substrate Structure

Product Information:

Product Name 10,11-dihydroxyspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8(9),10-triene-2,3'-cyclohexa-1,4-diene]-6'-one
Product Chemical FormulaC16H15NO3
Product SmilesC1C2=C3C(=C(O)C(O)=C2)C2(C=CC(=O)C=C2)CC3NC1
Product Structure

References:

Title: Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera).
PMID: 36805479
Journal: Sci Rep
Year: 2023/2/20

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics