Detail Information

P450 Protein:

P450 SymbolCYP80Q1
Protein Name(S)-N-methylcoclaurine 3'-hydroxylase isozyme 2
Uniprot ID
SpeciesNelumbo nucifera
Txid 4432
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO
RemarksGenBank: MG517489.1

Reaction Scheme:

Chemical Conversion C17H19NO3 → C17H17NO3
Reaction TypeCyclization
Chemical BondC=C;CH;C-OH

Machiline

CYP80Q1

11-Hydroxy-10-methoxyspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene-2,4'-cyclohexa-2,5-diene]-1'-one

Substrate Information:

Substrate Name Machiline
Substrate Chemical FormulaC17H19NO3
Substrate PubChem CID281691
Substrate SmilesC(OC)1C=C2CCNC(CC3C=CC(O)=CC=3)C2=CC=1O
Substrate Structure

Product Information:

Product Name 11-Hydroxy-10-methoxyspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene-2,4'-cyclohexa-2,5-diene]-1'-one
Product Chemical FormulaC17H17NO3
Product PubChem CID12304158
Product SmilesC(OC)1C(O)=C2C3(C=CC(=O)C=C3)CC3NCCC(=C32)C=1
Product Structure

References:

Title: Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera).
PMID: 36805479
Journal: Sci Rep
Year: 2023/2/20

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics