Detail Information
P450 Protein:
| P450 Symbol | CYP80Q2 |
| Protein Name | (S)-N-methylcoclaurine 3'-hydroxylase isozyme 2 |
| Uniprot ID | |
| Species | Nelumbo nucifera |
| Txid | 4432 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
| Remarks | GenBank:XM_010255687 |
Reaction Scheme:
| Chemical Conversion | C19H23NO3 → C38H44N2O6 |
| Reaction Type | Polymerization |
| Chemical Bond |
CYP80Q2
Substrate Information:
| Substrate Name | 4'-O-Methyl-N-methylcoclaurine |
| Substrate Chemical Formula | C19H23NO3 |
| Substrate PubChem CID | 3014795 |
| Substrate Smiles | C(OC)1C=C2CCN(C)C(CC3C=CC(OC)=CC=3)C2=CC=1O |
| Substrate Structure |
Product Information:
| Product Name | Neferine |
| Product Chemical Formula | C38H44N2O6 |
| Product PubChem CID | 398793 |
| Product Smiles | O(C)C1C=C2C(CC3=CC=C(O)C(OC4C=C5C(CC6C=CC(OC)=CC=6)N(C)CCC5=CC=4OC)=C3)N(C)CCC2=CC=1OC |
| Product Structure |
References:
| Title: | Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). |
| PMID: | 36805479 |
| Journal: | Sci Rep |
| Year: | 2023/2/20 |