Detail Information
P450 Protein:
| P450 Symbol | CYP3A4 |
| Protein Name | Cytochrome P450 3A4 |
| Uniprot ID | P08684 |
| EC Number | 1.14.14.1 |
| Gene ID | 1576 |
| Species | Homo sapiens |
| Txid | 9606 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C7H17O3PS3 → C7H17O5PS2 |
| Reaction Type | Oxidation |
| Chemical Bond | P=S |
CYP3A4
Substrate Information:
| Substrate Name | Phorate sulfoxide |
| Substrate Chemical Formula | C7H17O3PS3 |
| Substrate PubChem CID | 17424 |
| Substrate Smiles | CCOP(=S)(OCC)SCS(=O)CC |
| Substrate Structure |
Product Information:
| Product Name | Phoratoxon sulfone |
| Product Chemical Formula | C7H17O5PS2 |
| Product PubChem CID | 17427 |
| Product Smiles | CCOP(=O)(OCC)SCS(=O)(=O)CC |
| Product Structure |
References:
| Title: | Bioelectrochemical platform with human monooxygenases: FMO1 and CYP3A4 tandem reactions with phorate. |
| PMID: | 36446195 |
| Journal: | Bioelectrochemistry |
| Year: | 2022/11/23 |