Detail Information
P450 Protein:
| P450 Symbol | CYP154C8 |
| Protein Name | Steroid hydroxylase CYP154C8 |
| Uniprot ID | A0A2H4WK62 |
| Species | Streptomyces sp. |
| Txid | 1931 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C21H30O2 → C21H30O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Transformations | 1.Hydroxylation at an Aliphatic Carbon |
CYP154C8
Substrate Information:
| Substrate Name | Progesterone |
| Substrate Chemical Formula | C21H30O2 |
| Substrate PubChem CID | 5994 |
| Substrate Smiles | O=C1C=C2CCC3C(CCC4(C)C(C(=O)C)CCC34)C2(C)CC1 |
| Substrate Structure |
Product Information:
| Product Name | 16alpha-Hydroxyprogesterone |
| Product Chemical Formula | C21H30O3 |
| Product PubChem CID | 243761 |
| Product CAS Number | 438-07-3 |
| Product Smiles | O=C1C=C2CCC3C(CCC4(C)C(C(=O)C)C(O)CC34)C2(C)CC1 |
| Product Structure |
References:
| Title: | Efficient regio- and stereo-selective C–H bond hydroxylation of steroids using an engineered heme-thiolate peroxygenase biocatalyst |
| DOI: | https://doi.org/10.1039/D3CY01223A |
| Journal: | Catalysis Science & Technology |
| Year: | 2023/10/5 |