Detail Information
P450 Protein:
| P450 Symbol | CYP719A25 |
| Protein Name | stylopine synthase |
| Uniprot ID | |
| Species | Papaver somniferum |
| Txid | 3469 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C19H21NO4 → C19H19NO4 |
| Reaction Type | Cyclization |
| Chemical Bond | C-O |
CYP719A25
Substrate Information:
| Substrate Name | Scoulerine |
| Substrate Chemical Formula | C19H21NO4 |
| Substrate PubChem CID | 22955 |
| Substrate Smiles | C1C2=CC(=C(C=C2C2CC3=CC=C(OC)C(O)=C3CN2C1)O)OC |
| Substrate Structure |
Product Information:
| Product Name | Cheilanthifoline |
| Product Chemical Formula | C19H19NO4 |
| Product PubChem CID | 5117621 |
| Product Smiles | C1C(OC)=C(O)C=C2C3CC4=CC=C5OCOC5=C4CN3CCC=12 |
| Product Structure |
References:
| Title: | Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae. |
| PMID: | 24513861 |
| Journal: | Nature communications |
| Year: | 2014/2/11 |