Detail Information
P450 Protein:
| P450 Symbol | P450 SgvP |
| Protein Name | p450-like monooxygenase |
| Uniprot ID | R9USI6 |
| Species | Streptomyces griseoviridis |
| Txid | 45398 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C22H29N3O7S → C22H27N3O7S |
| Reaction Type | Oxidation |
| Chemical Bond | SH-CH |
| Solvents | Dimethyl sulfoxide;Water |
| Conditions | pH 8, rt |
P450 SgvP
Substrate Information:
| Substrate Name | A-2315A |
| Substrate Chemical Formula | C22H29N3O7S |
| Substrate PubChem CID | 6441077 |
| Substrate Smiles | C[CH]1/C=C/C(=O)NC/C=C/C(=C/[CH](C[CH](CC2=NC(=CO2)C(=O)N[CH](C(=O)O[CH]1C(C)C)C)O)O)/C |
| Substrate Structure |
Product Information:
| Product Name | Griseoviridin |
| Product Chemical Formula | C22H27N3O7S |
| Product PubChem CID | 11225326 |
| Product CAS Number | 53216-90-3 |
| Product Smiles | C[CH]1C/C=C2/C(=O)NC/C=C/C=C/[CH](C[CH](CC3=NC(=CO3)C(=O)N[CH](CS2)C(=O)O1)O)O |
| Product Structure |
References:
| Title: | Total Synthesis Facilitates In Vitro Reconstitution of the C-S Bond-Forming P450 in Griseoviridin Biosynthesis. |
| PMID: | 39042396 |
| Journal: | ChemRxiv |
| Year: | 2024/5/3 |