Detail Information
P450 Protein:
| P450 Symbol | CYP105D18 |
| Protein Name | Cytochrome P450 hydroxylase |
| Uniprot ID | A0A160P685 |
| Species | Streptomyces laurentii |
| Txid | 39478 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C19H28O2 → C19H28O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
| Solvents | H2O2 |
| Conditions | 1 h, 30°C |
| Transformations | 1.Reduction of Alcohols /Dehydroxylation |
CYP105D18
Substrate Information:
| Substrate Name | Testosterone |
| Substrate Chemical Formula | C19H28O2 |
| Substrate PubChem CID | 6013 |
| Substrate CAS Number | 58-22-0 |
| Substrate Smiles | O=C1C=C2CCC3C(CCC4(C)C(O)CCC34)C2(C)CC1 |
| Substrate Structure |
Product Information:
| Product Name | 2Beta-Hydroxytestosterone |
| Product Chemical Formula | C19H28O3 |
| Product PubChem CID | 14311667 |
| Product Smiles | O=C1C=C2CCC3C(CCC4(C)C(O)CCC34)C2(C)CC1O |
| Product Structure |
References:
| Title: | H(2)O(2)-Driven Hydroxylation of Steroids Catalyzed by Cytochrome P450 CYP105D18: Exploration of the Substrate Access Channel. |
| PMID: | 36511686 |
| Journal: | Applied and Environmental Microbiology |
| Year: | 2022/11/13 |