Detail Information

P450 Protein:

P450 SymbolAurH
Protein NamePutative cytochrome P450
Uniprot IDQ70KH6
EC Number1.14.15.37
Gene ID 66737957
SpeciesStreptomyces thioluteus
Txid 66431
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C16H21IO3 → C16H19IO4
Reaction TypeOxidation
Chemical BondCH
SolventsDimethyl sulfoxide, Water

methyl (6S)-3-iodo-6-phenylmethoxyoct-7-enoate

AurH

2-[(2R,4Z)-4-[(E)-3-iodo-2-methylprop-2-enylidene]oxolan-2-yl]-6-methoxy-3,5-dimethylpyran-4-one

Substrate Information:

Substrate Name methyl (6S)-3-iodo-6-phenylmethoxyoct-7-enoate
Substrate Chemical FormulaC16H21IO3
Substrate PubChem CID10981965
Substrate SmilesO=C1C(=C(OC(=C1C)CCC(=CC(=CI)C)C)OC)C
Substrate Structure

Product Information:

Product Name 2-[(2R,4Z)-4-[(E)-3-iodo-2-methylprop-2-enylidene]oxolan-2-yl]-6-methoxy-3,5-dimethylpyran-4-one
Product Chemical FormulaC16H19IO4
Product PubChem CID101738716
Product CAS Number1135345-08-2
Product SmilesO=C1C(=C(OC(=C1C)C2OCC(=CC(=CI)C)C2)OC)C
Product Structure

References:

Title: Chemoenzymatic total synthesis of the antiproliferative polyketide (+)-(R)-aureothin.
PMID: 18690656
Journal: ChemBioChem (2008)
Year: 2008/9/1

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics