Detail Information

P450 Protein:

P450 SymbolAurH
Protein NamePutative cytochrome P450
Uniprot IDQ70KH6
EC Number1.14.15.37
Gene ID 66737957
SpeciesStreptomyces thioluteus
Txid 66431
P450 Protein Structure
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence GO

Reaction Scheme:

Chemical Conversion C22H25NO5 + Fe2S2 + O2 + H+ → C22H23NO6 + Fe2S2 + H2O
Reaction TypeOxidation
Chemical BondCH
RheaID 58824

luteothin

+

[2Fe-2S]1+

+

O2

+

H+

AurH

aureothin

+

[2Fe-2S]2+

+

H2O

Substrate Information:

Substrate Name luteothin
Substrate Chemical FormulaC22H25NO5
Substrate PubChem CID11246062
Substrate SmilesCC1=C(OC(=C(C1=O)C)OC)CC/C(=C/C(=C/C2=CC=C(C=C2)[N+](=O)[O-])/C)/C
Substrate Structure
Substrate Name [2Fe-2S]1+
Substrate Chemical FormulaFe2S2
Substrate SmilesS1[Fe]S[Fe+]1
Substrate Structure
Substrate Name O2
Substrate Chemical FormulaO2
Substrate PubChem CID977
Substrate CAS Number7782-44-7
Substrate SmilesO=O
Substrate Structure
Substrate Name H+
Substrate Chemical FormulaH+
Substrate PubChem CID1038
Substrate CAS Number12408-02-5
Substrate Smiles[H+]
Substrate Structure

Product Information:

Product Name aureothin
Product Chemical FormulaC22H23NO6
Product PubChem CID6569946
Product SmilesCC1=C(OC(=C(C1=O)C)OC)C2CC(=CC(=CC3=CC=C(C=C3)[N+](=O)[O-])C)CO2
Product Structure
Product Name [2Fe-2S]2+
Product Chemical FormulaFe2S2
Product SmilesS1[Fe+]S[Fe+]1
Product Structure
Product Name H2O
Product Chemical FormulaH2O
Product PubChem CID962
Product CAS Number7732-18-5
Product SmilesO
Product Structure

References:

Title: Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase.
PMID: 15612710
Journal: Journal of the American Chemical Society
Year: 2004/12/3

Contact zhy1001@alu.uestc.edu.cn or yangzhang@cdutcm.edu.cn
© Department of Bioinformatics