Detail Information
P450 Protein:
| P450 Symbol | AurH |
| Protein Name | Putative cytochrome P450 |
| Uniprot ID | Q70KH6 |
| EC Number | 1.14.15.37 |
| Gene ID | 66737957 |
| Species | Streptomyces thioluteus |
| Txid | 66431 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C16H21IO3 → C16H19IO4 |
| Reaction Type | Oxidation |
| Chemical Bond | |
| Solvents | Dimethyl sulfoxide, Water |
AurH
Substrate Information:
| Substrate Name | 6-[(3E,5E)-6-iodo-3,5-dimethylhexa-3,5-dienyl]-2-methoxy-3,5-dimethyl-4H-pyran-4-one |
| Substrate Chemical Formula | C16H21IO3 |
| Substrate Smiles | O=C1C(C)=C(OC)OC(CC/C(/C)=C/C(/C)=C/I)=C1C |
| Substrate Structure |
Product Information:
| Product Name | 6-[(2R)-4-[(1Z,2E)-3-iodo-2-methylprop-2-enylidene]tetrahydro-2-furyl]-2-methoxy-3,5-dimethyl-4H-pyran-4-one |
| Product Chemical Formula | C16H19IO4 |
| Product Smiles | O=C1C(C)=C(OC)OC([C@@]([H])2OC/C(=CC(C)=CI)/C2)=C1C |
| Product Structure |
References:
| Title: | Chemoenzymatic total synthesis of the antiproliferative polyketide (+)-(R)-aureothin. |
| PMID: | 18690656 |
| Journal: | ChemBioChem (2008) |
| Year: | 2008/9/1 |