Detail Information
P450 Protein:
| P450 Symbol | CYP2B4 |
| Protein Name | Cytochrome P450 2B4 |
| Uniprot ID | P00178 |
| EC Number | 1.14.14.1 |
| Gene ID | 100327257 |
| Species | Oryctolagus cuniculus |
| Txid | 9986 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C6H7N + C21H26N7O17P3-4 → C6H7NO + C21H25N7O17P3-3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Water |
| Conditions | 30 min, pH 7.4 |
| Transformations | 1. Hydroxylation of Aromatic Compounds2. Hydroxylation at an Aromatic Carbon |
+
CYP2B4
+
Substrate Information:
| Substrate Name | Aniline |
| Substrate Chemical Formula | C6H7N |
| Substrate PubChem CID | 6115 |
| Substrate Smiles | C1=CC=C(C=C1)N |
| Substrate Structure |
| Substrate Name | NADPH(4-) |
| Substrate Chemical Formula | C21H26N7O17P3-4 |
| Substrate PubChem CID | 15983949 |
| Substrate Smiles | C1C=CN(C=C1C(=O)N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
Product Information:
| Product Name | 4-Aminophenol |
| Product Chemical Formula | C6H7NO |
| Product PubChem CID | 403 |
| Product CAS Number | 123-30-8 |
| Product Smiles | C1=CC(=CC=C1N)O |
| Product Structure |
| Product Name | NADP+ |
| Product Chemical Formula | C21H25N7O17P3-3 |
| Product PubChem CID | 162422398 |
| Product Smiles | C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)OP(=O)([O-])[O-])O)O)C(=O)N |
| Product Structure |
References:
| Title: | Catalytic activity of cytochrome P-450 using NADP+ reduced by an anionic hydride organosiloxane |
| DOI: | https://doi.org/10.3797/scipharm.0803-01 |
| Journal: | Scientia Pharmaceutica (2008) |
| Year: | 2008/4/21 |