Detail Information
P450 Protein:
| P450 Symbol | CYP1A2 |
| Protein Name | Cytochrome P450 1A2 |
| Uniprot ID | Q5KQT6 |
| EC Number | 1.14.14.1 |
| Gene ID | 13077 |
| Species | Felis catus |
| Txid | 9685 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H20O8 → C19H18O8 |
| Reaction Type | Demethylation |
| Chemical Bond | OCH3 |
| Solvents | Dimethylformamide, Water |
| Conditions | pH 7, 30°C |
| Transformations | 1. Formation of Alkyl Halides/ Alcohols from Ethers /Silyl Ethers |
CYP1A2
Substrate Information:
| Substrate Name | 3-Hydroxy-5,6,7,8,4′-pentamethoxyflavone |
| Substrate Chemical Formula | C20H20O8 |
| Substrate PubChem CID | 10715291 |
| Substrate Smiles | O=C1C(O)=C(OC=2C(OC)=C(OC)C(OC)=C(OC)C12)C=3C=CC(OC)=CC3 |
| Substrate Structure |
Product Information:
| Product Name | 3,4′-Dihydroxy-5,6,7,8-tetramethoxyflavone |
| Product Chemical Formula | C19H18O8 |
| Product PubChem CID | 16737088 |
| Product CAS Number | 945225-65-0 |
| Product Smiles | O=C1C(O)=C(OC2=C(OC)C(OC)=C(OC)C(OC)=C12)C=3C=CC(O)=CC3 |
| Product Structure |
References:
| Title: | Biotransformation of polymethoxylated flavonoids: access to their 4'-O-demethylated metabolites. |
| PMID: | 17559266 |
| Journal: | Journal of Natural Products (2007) |
| Year: | 2007/6/9 |