Detail Information
P450 Protein:
| P450 Symbol | crpE |
| Protein Name | ABC transporter protein |
| Uniprot ID | A0A067ZUX1 |
| Gene ID | 250344 |
| Species | Pseudomonas corrugata |
| Txid | 47879 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C35H44N2O7 → C35H44N2O8 |
| Reaction Type | Oxidation |
| Chemical Bond | C=C |
| Solvents | Dimethyl sulfoxide, Water |
| Conditions | 2 min, pH 7.4, 30°C; 2 - 4 h, 30°C |
| Transformations | 1. Epoxidation of Alkenes |
crpE
Substrate Information:
| Substrate Name | Cryptophycin D |
| Substrate Chemical Formula | C35H44N2O7 |
| Substrate PubChem CID | 10371453 |
| Substrate Smiles | CC1CNC(=O)C(NC(=O)C=CCC(OC(=O)C(OC1=O)CC(C)C)C(C)C=CC2=CC=CC=C2)CC3=CC=C(C=C3)OC |
| Substrate Structure |
Product Information:
| Product Name | (3E,7E)-2-hydroxy-8-[[(2R)-2-[[(E,5S,6S)-5-hydroxy-6-[(2R,3R)-3-phenyloxiran-2-yl]hept-2-enyl]amino]-3-(4-methoxyphenyl)propanoyl]amino]-4-methyl-6-oxonona-3,7-dienoic acid |
| Product Chemical Formula | C35H44N2O8 |
| Product PubChem CID | 6444183 |
| Product CAS Number | 155645-50-4 |
| Product Smiles | CC(C1C(O1)C2=CC=CC=C2)C(CC=CCNC(CC3=CC=C(C=C3)OC)C(=O)NC(=CC(=O)CC(=CC(C(=O)O)O)C)C)O |
| Product Structure |
References:
| Title: | Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts. |
| PMID: | 17240975 |
| Journal: | ACS Chemical Biology (2006) |
| Year: | 2006/12/15 |