Detail Information
P450 Protein:
| P450 Symbol | CYP102A1 |
| Protein Name | Bifunctional cytochrome P450/NADPH--P450 reductase |
| Uniprot ID | P14779 |
| EC Number | 1.14.14.1 |
| Gene ID | 93643681 |
| Species | Priestia megaterium (strain ATCC 14581 / DSM 32 / CCUG 1817 / JCM 2506 / NBRC 15308 / NCIMB 9376 / NCTC 10342 / NRRL B-14308 / VKM B-512 / Ford 19) |
| Txid | 1348623 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C14H28O3 → C14H28O4 |
| Reaction Type | Oxidation |
| Chemical Bond | CH2 |
| Solvents | Water |
| Conditions | 1 h, pH 8 |
| Transformations | 1. Hydroxylation at an Aliphatic Carbon |
CYP102A1
Substrate Information:
| Substrate Name | (13R)-13-Hydroxytetradecanoic acid |
| Substrate Chemical Formula | C14H28O3 |
| Substrate PubChem CID | 11086022 |
| Substrate Smiles | CC(CCCCCCCCCCCC(=O)O)O |
| Substrate Structure |
Product Information:
| Product Name | (12R,13R)-12,13-Dihydroxytetradecanoic acid |
| Product Chemical Formula | C14H28O4 |
| Product PubChem CID | 10890637 |
| Product CAS Number | 252979-94-5 |
| Product Smiles | CC(C(CCCCCCCCCCC(=O)O)O)O |
| Product Structure |
References:
| Title: | An unusual matrix of stereocomplementarity in the hydroxylation of monohydroxy fatty acids catalysed by cytochrome P450 from Bacillus megaterium with potential application in biotransformations |
| DOI: | https://doi.org/10.1039/A905974A |
| Journal: | Chemical Communications (Cambridge) (1999) |
| Year: | 1999/9/6 |