Detail Information
P450 Protein:
| P450 Symbol | CYP2B4 |
| Protein Name | Cytochrome P450 2B4 |
| Uniprot ID | P00178 |
| EC Number | 1.14.14.1 |
| Gene ID | 100327257 |
| Species | Oryctolagus cuniculus |
| Txid | 9986 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C11H11F3 → C11H11F3O |
| Reaction Type | Oxidation |
| Chemical Bond |
CYP2B4
Substrate Information:
| Substrate Name | 1-(2-Methylcyclopropyl)-4-(trifluoromethyl)benzene |
| Substrate Chemical Formula | C11H11F3 |
| Substrate PubChem CID | 13275083 |
| Substrate Smiles | CC1CC1C2=CC=C(C=C2)C(F)(F)F |
| Substrate Structure |
Product Information:
| Product Name | alpha-2-Propen-1-yl-4-(trifluoromethyl)benzenemethanol |
| Product Chemical Formula | C11H11F3O |
| Product PubChem CID | 10536669 |
| Product CAS Number | 144486-12-4 |
| Product Smiles | C=CCC(C1=CC=C(C=C1)C(F)(F)F)O |
| Product Structure |
References:
| Title: | Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions |
| DOI: | https://doi.org/10.1021/ja981990f |
| Journal: | Journal of the American Chemical Society (1998) |
| Year: | 1998/9/5 |