Detail Information
P450 Protein:
| P450 Symbol | CYP7B1 |
| Protein Name | Cytochrome P450 7B1 |
| Uniprot ID | Q60991 |
| EC Number | 1.14.14.26 |
| Gene ID | 13123 |
| Species | Mus musculus |
| Txid | 10090 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C21H32O2 → C21H32O3 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Solvents | Water |
| Conditions | rt; 10 min, rt→37°C |
| Transformations | 1. Hydroxylation at an Aliphatic Carbon |
CYP7B1
Substrate Information:
| Substrate Name | Pregn-5-en-20-one-20-14C, 3beta-hydroxy- |
| Substrate Chemical Formula | C21H32O2 |
| Substrate Smiles | O=C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
| Substrate Structure |
Product Information:
| Product Name | (3beta,7alpha)-3,7-Dihydroxypregn-5-en-20-one-20-14C |
| Product Chemical Formula | C21H32O3 |
| Product CAS Number | 1002723-45-6 |
| Product Smiles | O=C(C)C1CCC2C3C(O)C=C4CC(O)CCC4(C)C3CCC12C |
| Product Structure |
References:
| Title: | Hydroxylation of pregnenolone at the 7 alpha- and 7 beta- positions by mouse liver microsomes. Effects of cytochrome p450 inhibitors and structure-specific inhibition by steroid hormones. |
| PMID: | 9654644 |
| Journal: | Steroids (1998) |
| Year: | / |