Detail Information
P450 Protein:
| P450 Symbol | CYP1A1 |
| Protein Name | Cytochrome P450 1A1 |
| Uniprot ID | P00185 |
| EC Number | 1.14.14.1 |
| Gene ID | 24296 |
| Species | Rattus norvegicus |
| Txid | 10116 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H20O7 → C19H18O7 |
| Reaction Type | Oxidation |
| Chemical Bond | OCH3 |
| Solvents | Dimethyl sulfoxide, Water |
| Conditions | 20 min, pH 7.4, 37°C |
| Transformations | 1. Formation of Alkyl Halides/ Alcohols from Ethers /Silyl Ethers |
CYP1A1
Substrate Information:
| Substrate Name | Tangeretin |
| Substrate Chemical Formula | C20H20O7 |
| Substrate PubChem CID | 68077 |
| Substrate Smiles | COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC |
| Substrate Structure |
Product Information:
| Product Name | 4′-Hydroxy-5,6,7,8-tetramethoxyflavone |
| Product Chemical Formula | C19H18O7 |
| Product PubChem CID | 3010100 |
| Product CAS Number | 36950-98-8 |
| Product Smiles | COC1=C(C(=C(C2=C1C(=O)C=C(O2)C3=CC=C(C=C3)O)OC)OC)OC |
| Product Structure |
References:
| Title: | In vitro biotransformation of flavonoids by rat liver microsomes. |
| PMID: | 9604302 |
| Journal: | Xenobiotica (1998) |
| Year: | 1997/9/13 |