Detail Information
P450 Protein:
| P450 Symbol | CYP1A1 |
| Protein Name | Cytochrome P450 1A1 |
| Uniprot ID | P00185 |
| EC Number | 1.14.14.1 |
| Gene ID | 24296 |
| Species | Rattus norvegicus |
| Txid | 10116 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C16H14O6 → C15H12O6 |
| Reaction Type | Oxidation |
| Chemical Bond | OCH3 |
| Solvents | Dimethyl sulfoxide, Water |
| Conditions | 20 min, pH 7.4, 37°C |
| Transformations | 1. Formation of Alkyl Halides/ Alcohols from Ethers /Silyl Ethers |
CYP1A1
Substrate Information:
| Substrate Name | Hesperetin |
| Substrate Chemical Formula | C16H14O6 |
| Substrate PubChem CID | 72281 |
| Substrate Smiles | COC1=C(C=C(C=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O |
| Substrate Structure |
Product Information:
| Product Name | (+)-Eriodictyol |
| Product Chemical Formula | C15H12O6 |
| Product PubChem CID | 440735 |
| Product CAS Number | 552-58-9 |
| Product Smiles | C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(C=C3)O)O |
| Product Structure |
References:
| Title: | In vitro biotransformation of flavonoids by rat liver microsomes. |
| PMID: | 9604302 |
| Journal: | Xenobiotica (1998) |
| Year: | 1997/9/13 |